Coagulation factor IX

• The test material is blood.
• The patient does not need to be fasting.

Samples brought from outside are not accepted for testing.

Clotting factor IX (FIX, Christmas factor, anti-hemophilic factor B)
FIX is a vitamin K-dependent glycoprotein and is activated by VIIa/TForXIa. Once activated, factor IXa in the presence of factor VIIIa, platelet phospholipids and calcium ions activates factor X. FVIIIa is an essential cofactor of factor IXa. Hence, deficiency of one or the other factor has a similar clinical picture. Hemophilia B is associated with FIX deficiency. In laboratory tests, most cases of hemophilia B show prolonged APTT with normal INR. Factor IX determination is necessary to establish the diagnosis.
Reduced FIX activity occurs in:
- Congenital factor IX deficiency ( hemophilia B)
- Treatment with vitamin K antagonists
- Significant liver damage
- Amyloidosis
- Treatment with valproic acid
- Vitamin K deficiency
- Acquired FIX deficiency ( rarely in cancer and autoimmune diseases, after surgeries)

Increased FIX activity occurs in:
- Diabetes
- Corticosteroid therapy
Increased FIX activity is associated with an increased risk of cardiovascular incidents. It is recommended that this protein be assayed for the diagnosis of thrombosis of unknown cause with zylosis.

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