Coagulation factor VII

• The test material is blood.
• The patient does not need to be fasting.

Samples brought from outside are not accepted for testing.

Factor VII ( proconvertin, F VII) is one of the vitamin K-dependent extrinsic blood coagulation factors, synthesized in the liver. It is secreted into the blood in an inactive form. Its conversion occurs under the influence of active clotting factors, as well as by autocatalysis under the influence of FVIIa, whose concentration is very low. Circulating F VIIa combines with TissueFactor (TF) to form the TF-F VIIa comlex, which rapidly accelerates further FVII activation and thrombin generation. Activation of factor VII to VIIa is also catalyzed by other proteins: thrombin and factor X, as well as factors IXa, Xa, XIa, XIIa. Activated factor VIIa in complex with TF activates factors X and IX leading to coagulation reactions. The physiological inhibitor of this process is TFPI (TissueFactorPathway Inhibitor).
Clotting factor VII is assayed in cases of deficiency or increased activity, as well as in cases of abnormal PT and aPTT results and in the presence of abnormal bleeding or thrombotic incidents.

Factor VII deficiency is a rare disease associated with quantitative (concentration) or qualitative (activity) changes, leading to bleeding. . Factor VII activity of less than 1% can cause life-threatening bleeding, with joint and central nervous system hemorrhages. Factor VII deficiency can be associated with taking oral anticoagulants, cephalosporins or penicillin.

An increase in the amount of the factor, caused by mutation, an increase in TF expression, hypertension, diabetes mellitus - especially complicated by microalbuminuria, leads to the development of thrombotic diseases.
Factor VII, in addition to platelets, is one of the main causes of thrombin and fibrin generation in the area of atherosclerotic plaques, which leads to the growth of a clot and the development of atherosclerosis and acute vascular incidents. For this reason, it is one of the risk factors for atherosclerosis and progression of ischemic heart disease.

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