von Willebrand factor-antigen

• The test material is blood.
• The patient does not need to be fasting.

Samples brought from outside are not accepted for testing.

von Willebrand factor is a blood plasma glycoprotein built from multimers formed from subunits weighing about 250 kDa. ThevWF multimers promote platelet adhesion at the site of blood vessel injury by binding to collagen and platelets. vWF binds to and stabilizes factor VIII, hence vWF defects cause bleeding similar to the bleeding associated with platelet dysfunction or seen in hemophilia. von Willebrand disease is a congenital blood coagulation disorder associated with a quantitative or qualitative deficiency of von Willebrand factor.
Acquired von Willebrand syndrome is associated with vWF deficiency and decreased vWF activity, which is sometimes seen in lympho or myeloproliferative diseases, in cancer and in autoimmune diseases.
Many patients with mild disease may not have clinical symptoms of the disease. The most common symptoms include:
- excessive menstrual bleeding
- easy bruising
- nose and gum bleeding
- prolonged bleeding from small wounds
- bleeding after tooth extraction
- bleeding after trauma or surgery
- delivery and intramuscular hemorrhages similar to those in hemophilia.

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